BDBM50419689 CHEMBL1945033

SMILES O[C@@H](CNCCc1cccc(CNCCc2ccccn2)c1)c1ccc(O)c2[nH]c(=O)sc12

InChI Key InChIKey=WWEHZPFFGZLBOV-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50419689   

TargetBeta-2 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataIC50: 2.5nMAssay Description:Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Guinea pig)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataEC50:  0.316nMAssay Description:Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataIC50: 158nMAssay Description:Displacement of radiolabeled iodocyanopindolol from beta1 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataIC50: 200nMAssay Description:Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419689(CHEMBL1945033)
Affinity DataIC50: 1.59E+3nMAssay Description:Binding affinity to dopamine D2 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed