BDBM50418165 CHEMBL1761512

SMILES CCCS(=O)(=O)N1CCC(CC1)c1c[nH]c2c(cc(cc12)-c1ccccc1)C(N)=O

InChI Key InChIKey=ZJPQAWUONSYBKW-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50418165   

LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IKK-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 158nMAssay Description:Inhibition of IKK-beta in human PBMC assessed as TNF-alpha-induced Nuclear factor-kappa-B nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of IKK-epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of TBK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 12.6nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to FLT3 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50418165(CHEMBL1761512)
Affinity DataIC50: 13nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed