BDBM50415268 CHEMBL595607

SMILES Cn1c(CN2CCN(CC2)c2ccc(Cl)cc2F)nc2ccccc12

InChI Key InChIKey=HBKFRQKTXQIBDE-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50415268   

TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415268(CHEMBL595607)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415268(CHEMBL595607)
Affinity DataEC50:  2.51E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415268(CHEMBL595607)
Affinity DataKi:  251nMAssay Description:Antagonist activity at human D4 receptor expressed in HEK293 cells co-expressing Gqo5 G-protein by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed