BDBM50414629 CHEMBL563471

SMILES Cn1cc(cn1)-c1cccc(CC(NC(=O)c2cc(nn2C)C(C)(C)C)C(=O)NCC#N)c1

InChI Key InChIKey=MNHLKDOPYXSVAC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50414629   

TargetCathepsin L2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 158nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 316nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414629(CHEMBL563471)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed