BDBM50413966 CHEMBL489917

SMILES COc1cc(OC)cc(c1)C(=O)NC(NC(Nc1cccnc1OC)=NC#N)C(C)(Cl)Cl

InChI Key InChIKey=WMOGCVKVEBMEHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50413966   

TargetP2X purinoceptor 7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50413966(CHEMBL489917)
Affinity DataIC50: 50.1nMAssay Description:Antagonist activity at human cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50413966(CHEMBL489917)
Affinity DataIC50: 19.9nMAssay Description:Antagonist activity at rat cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed