BDBM50413562 CHEMBL469375

SMILES CN1C(=O)COc2c(CCCN3CCN(CC3)c3cccc4nc(C)ccc34)cccc12

InChI Key InChIKey=LXAUCMFDVSJMGT-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50413562   

Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataEC50:  63.1nMAssay Description:Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]citalopram human SerT receptor expressed in LLCPK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataKi:  1.58nMAssay Description:Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413562(CHEMBL469375)
Affinity DataKi:  5.01E+3nMAssay Description:Displacement of [3H]dofetilide human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed