BDBM50412863 CHEMBL359632::JNJ-10397049

SMILES CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2Br)[C@@H](O1)c1ccccc1

InChI Key InChIKey=RBKIJGLHFFQHBE-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50412863   

TargetOrexin receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-orexin A from OX2 receptor (unknown origin) expressed in CHOK1 cells after 90 to 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  5nMAssay Description:Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to OX1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  6nMAssay Description:Binding affinity to orexin receptor 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  1.35E+3nMAssay Description:Displacement of [3H]-SB67404 from human orexin 1 receptor expressed in CHO cells incubated for 2 hrs by whole cell radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  1.64E+3nMAssay Description:Binding affinity to orexin receptor 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [125I]-orexin A from OX1 receptor (unknown origin) expressed in CHOK1 cells after 90 to 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50412863(JNJ-10397049 | CHEMBL359632)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity to OX2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed