BDBM50409708 CHEMBL400694

SMILES CC[C@@]1(CCCCN(C)C1=O)c1cccc(Oc2cc(ccc2C#N)[C@@](C)(N)c2cncn2C)c1

InChI Key InChIKey=MHNMEERHZSPWFL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50409708   

TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50409708(CHEMBL400694)Copy SMILESCopy InChI

Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/27/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50409708(CHEMBL400694)Copy SMILESCopy InChI

Affinity DataIC50: 54nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/27/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL