BDBM50406178 CHEMBL5267934::US20240190892, Example 20

SMILES Cc1cnn(Cc2ccc(CNC(=O)c3cncc(c3)N3CC[C@]4(C3)OC(=O)Nc3ccc(Cl)c(F)c43)cn2)c1

InChI Key InChIKey=CKAXHHJAPBSNRU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50406178   

TargetPlasma kallikrein(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50406178(CHEMBL5267934 | US20240190892, Example 20)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human plasma kallikrein using Acetyl-K- P-R-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50406178(CHEMBL5267934 | US20240190892, Example 20)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human factor 11a using GPR-AFC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50406178(CHEMBL5267934 | US20240190892, Example 20)
Affinity DataIC50: 1.30nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of plasma kallikrein can be determined using a relevant purified serine prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50406178(CHEMBL5267934 | US20240190892, Example 20)
Affinity DataIC50: 1.00E+4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent