BDBM50405519 CHEMBL5278314

SMILES COc1cccc(OC)c1[C@@H]1CC[C@@H](CC1)N1CCN(CC1)C1CCCCC1

InChI Key InChIKey=KUABCMYWOYJHGI-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50405519   

TargetATP-dependent translocase ABCB1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataEC50:  800nMAssay Description:Inhibition of P-gp transporter (unknown origin) expressed in dog MDCK-MDR1 assessed as inhibition of fluorescent Calcein-AM transport by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membranes assessed as inhibition constant by radioligand binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50405519(CHEMBL5278314)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed