BDBM504049 (1R,2S)—N-(8-amino-5-cyclopropyl-6-(4-methylpyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(cyanomethyl)cyclopropanecarboxamide (Compound 316) and (1S,2R)—N-(8-amino-5-cyclopropyl-6-(4-methylpyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(cyanomethyl)cyclopropanecarboxamide ::US11034692, Compound 317

SMILES Cc1ccncc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1C1CC1

InChI Key InChIKey=AEPHQPLBKCBIPH-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504049   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

US Patent

LigandBDBM504049((1R,2S)—N-(8-amino-5-cyclopropyl-6-(4-methylp...)Copy SMILESCopy InChI

Affinity DataKi:  0.0200nMAssay Description:Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/5/2021
Entry Details
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