BDBM50404035 CHEMBL5287177

SMILES CC(C)(C)NS(=O)(=O)c1cccc(NC(=O)c2ncc(NS(C)(=O)=O)nc2N2CCC3(CC3)CC2)n1

InChI Key InChIKey=QEJRJBGBBKFHPC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50404035   

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM50404035(CHEMBL5287177)
Affinity DataIC50: 96nMAssay Description:Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetKinesin-like protein KIF11(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM50404035(CHEMBL5287177)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant GST-tagged human Eg5 assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM50404035(CHEMBL5287177)
Affinity DataIC50: 8.60E+4nMAssay Description:Inhibition of recombinant GST-tagged human CENP-E assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetKinesin-like protein KIF18A(Mouse)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM50404035(CHEMBL5287177)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant His-tagged mouse KIF18A expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed