BDBM50403298 CHEMBL5187263

SMILES Cc1c(cn2ccnc2c1CN3CCN([C@H](C3)C)C(=O)C4CCCC4)NC(=O)c5cnc(nc5)C

InChI Key InChIKey=GMRCLEMCHGYDSY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50403298   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50403298(CHEMBL5187263)
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at His tagged human RORgammat incubated for 1 hrs in presence of biotinylated co-activator peptide by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50403298(CHEMBL5187263)
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at His-tagged human RORgammat LBD assessed as inhibition of biotinylated RIP140 co-activator peptide binding incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)