BDBM50403063 CHEMBL2216862::US9321773, 15

SMILES COc1cccc(Cn2c(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc34)nc3cccc(C#C)c3c2=O)c1

InChI Key InChIKey=YSQFSEVNOOJNRC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50403063   

LigandPNGBDBM50403063(CHEMBL2216862 | US9321773, 15)
Affinity DataIC50: 4nMAssay Description:PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

LigandPNGBDBM50403063(CHEMBL2216862 | US9321773, 15)
Affinity DataIC50: 289nMAssay Description:PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

LigandPNGBDBM50403063(CHEMBL2216862 | US9321773, 15)
Affinity DataIC50: 1.97E+3nMAssay Description:PI3 kinases catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

LigandPNGBDBM50403063(CHEMBL2216862 | US9321773, 15)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403063(CHEMBL2216862 | US9321773, 15)
Affinity DataIC50: 570nMAssay Description:Inhibition of PI3Kdelta assessed as inhibition of H2O2-induced AKT phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed