BDBM50403022 CHEMBL2216760

SMILES CCCCc1nc2c(N)nc3cc(ccc3c2n1CC(C)(C)O)C(=O)OC

InChI Key InChIKey=VMUKZTRCWGVBDU-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50403022   

TargetToll-like receptor 8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  4.13E+4nMAssay Description:Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2020
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  2.09E+4nMAssay Description:Agonist activity at human TLR8 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2020
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  4.96E+4nMAssay Description:Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403022(CHEMBL2216760)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed