BDBM50402417 CHEMBL2208024

SMILES CC(=O)Nc1ccc(cc1)-c1ccnc(Nc2cccc(c2)N2CCCCC2)n1

InChI Key InChIKey=ZOTCIBXODUTCKF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50402417   

TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50: 956nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50: 980nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50: 14nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed