BDBM50402166 CHEMBL2207988

SMILES Cc1csc(n1)-c1[nH]cnc1-c1ccc2ncsc2c1

InChI Key InChIKey=LLFCXRYULHMNCG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50402166   

TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human GST tagged TGFbeta 1 using 3,3',5,5'-tetramethylbenzidine as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Minzu University of China

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50: 836nMAssay Description:Inhibition of human GST tagged ALK3 incubated for 30 mins in presence of ATP by QSSA Kit methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed