BDBM50401630 CHEMBL2203838

SMILES CNc1cc(Nc2cnc(C#N)c(O[C@@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1

InChI Key InChIKey=CYGOQLUBSPEPOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50401630   

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50401630(CHEMBL2203838)
Affinity DataIC50: 169nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50401630(CHEMBL2203838)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as etoposide-induced G2 check point arrest after 21 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed