BDBM50401266 CHEMBL2206916::US8772480, 367

SMILES CC(C)N(C)S(=O)(=O)Nc1cc(Nc2ncccc2-c2nc(C)nc(N)n2)cnc1Cl

InChI Key InChIKey=KRDRDADGCWRDPV-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50401266   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandPNGBDBM50401266(CHEMBL2206916 | US8772480, 367)
Affinity DataIC50: 420nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
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LigandPNGBDBM50401266(CHEMBL2206916 | US8772480, 367)
Affinity DataKi:  43nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha expressed in baculovirus infected Hi5 cells using Phosphatidylinositol-4,5-bisphosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50401266(CHEMBL2206916 | US8772480, 367)
Affinity DataKi:  44nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent