BDBM50401091 CHEMBL2204436::CHEMBL2385894

SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1

InChI Key InChIKey=PXQNLQLMRMROSB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50401091   

TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 1.70E+4nMAssay Description:Negative allosteric modulation of human mGlu2 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 4.20E+3nMAssay Description:Negative allosteric modulation of human mGlu3 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 4.20E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thallium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 1.70E+4nMAssay Description:Negative allosteric modulation of mGlu2 assessed as thallium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 190nMAssay Description:Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2385894 | CHEMBL2204436)
Affinity DataIC50: 1.25E+4nMAssay Description:Negative allosteric modulation of human mGlu2 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed