BDBM50401086 CHEMBL2204445

SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1

InChI Key InChIKey=VSLWUPHHCFQTDB-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50401086   

TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 1.50E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thallium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 1.48E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thallium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 660nMAssay Description:Negative allosteric modulation of mGlu3 assessed as inhibition of glutamate-induced calcium mobilization in presence of Galpha15 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of mGlu5 assessed as inhibition of glutamate-induced calcium mobilization by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu5 assessed as potentiation of glutamate-induced calcium mobilization by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of mGlu2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed