BDBM50399448 CHEMBL1230189

SMILES CN1Cc2ccccc2NC1=O

InChI Key InChIKey=GINUUQLRYXHAPB-UHFFFAOYSA-N

Data  2 IC50  8 Kd

PDB links: 4 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50399448   

TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of CBP (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  2.04E+4nMAssay Description:Binding affinity to human His10-tagged BRD4 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 using 0.5% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  5.03E+4nMAssay Description:Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 0.5% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  1.02E+5nMAssay Description:Binding affinity to human His10-tagged BRD4 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 using 3% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  3.10E+5nMAssay Description:Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 3% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to human His10-tagged BRD4 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 using methanol by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  1.03E+5nMAssay Description:Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using 1% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  3.77E+4nMAssay Description:Binding affinity to human His10-tagged CREBBP expressed in Escherichia coli BL21(DE3)-R3 using methanol by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399448(CHEMBL1230189)
Affinity DataKd:  3.89E+4nMAssay Description:Binding affinity to human His10-tagged BRD4 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 using 1% DMSO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed