BDBM50399293 CHEMBL2086582

SMILES COc1ccc(cc1)-c1cc(NC(=O)CCCCN2CCCN(CC2)C(C)=O)[nH]n1

InChI Key InChIKey=LKMWIEHGNOUIAH-UHFFFAOYSA-N

Data  1 KI  3 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50399293   

TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of m-chlorophenylbiguanide-induced calcium influx measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in CHO cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by IonWorks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataEC50:  180nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataEC50:  126nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399293(CHEMBL2086582)
Affinity DataKi:  660nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in GH4C1 cells after 1 hr by TopCount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed