BDBM50399088 CHEMBL2179319

SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1

InChI Key InChIKey=BQAVZGJJQFJSMW-UHFFFAOYSA-N

Data  1 KI  6 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50399088   

TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataEC50:  17nMAssay Description:Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataIC50: 15nMAssay Description:Binding affinity to human mGlu2R expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human mGlu2R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataEC50:  17nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataEC50:  4.80nMAssay Description:Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataEC50:  147nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed