BDBM50398720 CHEMBL2179619::US10227295, Compound 5h::US9409858, 5h::US9751832, Compound 5h::US9956192, Compound 5h

SMILES ONC(=O)c1ccc(CN(CCc2ccccc2)C(=O)Nc2ccccc2)cc1

InChI Key InChIKey=GAWCRHBRHJEZOZ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50398720   

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 3.12E+3nMpH: 8.0Assay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 14nMpH: 8.0Assay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 3.12E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 14nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 3.12E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 14nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 3.12E+3nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM50398720(CHEMBL2179619 | US9409858, 5h | US9751832, Compoun...)
Affinity DataIC50: 14nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent