BDBM50398090 CHEMBL2182050::US9321738, 13

SMILES C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(cc1)-c1ccc(cc1)C1(CC1)C(=O)NS(C)(=O)=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=IKJZZCLSUSZHFO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50398090   

TargetLysophosphatidic acid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50398090(CHEMBL2182050 | US9321738, 13)
Affinity DataIC50: 24.5nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetLysophosphatidic acid receptor 3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50398090(CHEMBL2182050 | US9321738, 13)
Affinity DataIC50: 65.7nMT: 2°CAssay Description:Test compounds were prepared by adding 90 μL of HBSS/20 mM HEPES/0.1% BSA buffer to 2 μL of serially diluted compounds. To prepare serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetLysophosphatidic acid receptor 3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50398090(CHEMBL2182050 | US9321738, 13)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human recombinant LPA3 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50398090(CHEMBL2182050 | US9321738, 13)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human recombinant LPA1 expressed in chem-1 cells assessed as inhibition of LPA-induced intracellular calcium mobilization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed