BDBM50398017 CHEMBL2180411::US9018217, 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine::US9592230, 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine

SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12

InChI Key InChIKey=AZOOBRKWMCUHJL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50398017   

LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50: 0.320nMT: 2°CAssay Description:A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2015
Entry Details
Go to US Patent

LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50: 0.320nMAssay Description:A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2019
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed