BDBM50397994 CHEMBL2180405::Roche-Dataset for PDE10A, Compound 531

SMILES O=C(Nc1ccn2cc(nc2n1)-c1ccccc1)c1nc(ccc1Nc1cncnc1)C1CC1

InChI Key InChIKey=SYPRSJMEVONNBB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397994   

LigandPNGBDBM50397994(CHEMBL2180405 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50397994(CHEMBL2180405 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 6.26nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed