BDBM50397830 CHEMBL2151164

SMILES COc1nc(Nc2cccc3n(C)c(nc23)-c2ccc(F)cc2)ccc1-n1cnc(C)c1

InChI Key InChIKey=ZQYDYFCAHHBFKE-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50397830   

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 8.50E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutical Companies of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrometorphan as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50: 8.50E+3nMAssay Description:Displacement of [3H]dofetilide to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed