BDBM50397360 CHEMBL2170177::US10188756, Compound CN110

SMILES COc1ccc(cc1)Cn2ccc3c2cc(cc3)C(=O)NO

InChI Key InChIKey=AJRGHIGYPXNABY-UHFFFAOYSA-N

Data  88 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 92 hits for monomerid = 50397360   

TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 26nMAssay Description:Inhibition of human HDAC8 using ZMTFAL as substrate measured after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to His-tagged recombinant human HDAC8 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 482nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC11 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC8 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human HDAC6 expressed in baculovirus expression system using FAM-RHKK(Ac)-NH2 substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal His-tagged and N-terminal GST-tagged full length human HDAC3 expressed in baculovirus expression system co-expressed with hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate preincubated for 15 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 133nMAssay Description:Binding affinity to human HDAC8 pre-incubated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of recombinant full-length C-terminal FLAG-fused/His-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected insect cells measured after 40 mins by HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 (unknown origin) preincubated for 15 mins followed by acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of recombinant human full-length C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-L-Lys(Ac)-AMC as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) expressed in Escherichia coli using fluor de Lys(R) as substrate pretreated for 5 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal His-tagged HDAC3 (395 to 489 residues)/human NCOR2 expressed in baculovirus infected Sf9 insec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal FLAG-His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using Boc-L-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataKd:  9.20nMAssay Description:Binding affinity to HDAC8 (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant HDAC8 using H2N-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 90 mins by fluorescence based micro plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 440nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC8 (unknown origin) (1 to 377 residues) expressed in Escherichia coli BL21(DE3) cells using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) (648 to 1057 residues) expressed in Escherichia coli BL21(DE3) cells using Boc-Lys(TFA)-AMC as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
Martin-Luther University of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataKd:  367nMAssay Description:Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC3/NCoR2 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066residues) expressed in baculovirus expression system using FAM-RHK(TF-Ac)-NH2 substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC10 expressed in baculovirus expression system using FAM-TSRHK(Ac)KL-NH2 substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC5 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal GST-tagged human HDAC4 (101 to 1084 resides) expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human HDAC2 expressed in baculovirus expression system using FAM-TSRHK(Ac)KL-NH2 substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG and His-tagged full length human HDAC1 expressed in baculovirus expression system using FAM-TSRHK(Ac)KL-NH2 substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC4 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 18.3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50: 7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

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