BDBM50395220 CHEMBL2164664::US9150581, RTI-7527-(+/-)-154

SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2

InChI Key

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50395220   

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi:  0.0800nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi:  0.0820nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi:  0.170nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi: >2.00E+3nMAssay Description:Compounds (10 mM) were also evaluated for inhibition of binding to a7 nAChR using [125I]iodoMLA as previously reported in Carroll et al. The binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed