BDBM50393851 CHEMBL1221983

SMILES CNC1CCC(CC1)N(Cc2cccc(c2)c3ccncc3)C(=O)c4c(c5ccccc5s4)Cl

InChI Key InChIKey=VFSUUTYAEQOIMW-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393851   

TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  130nMAssay Description:Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  30nMAssay Description:Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcriptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  8.80nMAssay Description:Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50393851(CHEMBL1221983)
Affinity DataEC50:  17nMAssay Description:Agonist activity at SMO in mouse NIH3T3 cells incubated for 2 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed