BDBM50393832 CHEMBL2159739

SMILES CCn1c(C)c(C(O)=O)c(c1-c1ccc(Cl)cc1)-c1cccc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN(C)C)CSc3ccccc3)c(c2)[N+]([O-])=O)cc1

InChI Key InChIKey=PYQJFMBPKZZCMB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50393832   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393832(CHEMBL2159739)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human N-terminal His8-tagged Mcl1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BID binding aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393832(CHEMBL2159739)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393832(CHEMBL2159739)
Affinity DataIC50: 6.60nMAssay Description:Binding affinity to BCL-XL (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393832(CHEMBL2159739)
Affinity DataIC50: 2nMAssay Description:Binding affinity to BCL2 (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed