BDBM50393509 PYRIDOPYRIDAZINONE

SMILES [O-][N+](=O)c1cccc(c1)-c1nn(Cc2ccncc2)c(=O)c2cccnc12

InChI Key InChIKey=DYHGFTMEUMYPOC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393509   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393509(PYRIDOPYRIDAZINONE)
Affinity DataIC50: 340nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50393509(PYRIDOPYRIDAZINONE)
Affinity DataEC50:  220nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50393509(PYRIDOPYRIDAZINONE)
Affinity DataIC50: 5nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed