BDBM50393305 CHEMBL2131608

SMILES OCC1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1

InChI Key InChIKey=VGPKJHVAVZKEKA-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393305   

TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393305(CHEMBL2131608)
Affinity DataEC50:  1.16E+4nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393305(CHEMBL2131608)
Affinity DataEC50:  1.21E+4nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393305(CHEMBL2131608)
Affinity DataEC50:  2.29E+4nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed