BDBM50393095 CHEMBL2152910::US9346827, 14

SMILES NC1=N[C@@]2(COCC1)c1cc(ccc1Oc1cnc(cc21)-c1ccnc(F)c1)-c1cccnc1F

InChI Key InChIKey=ZASOWXQELAKJDI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393095   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM50393095(CHEMBL2152910 | US9346827, 14)
Affinity DataIC50: 0.5nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM50393095(CHEMBL2152910 | US9346827, 14)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 expressed in HEK cells by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM50393095(CHEMBL2152910 | US9346827, 14)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed