BDBM50393041 CHEMBL2152711

SMILES CC(C)C(=O)NCc1ccc(Cl)c(c1)C(=O)Nc1ncc[nH]1

InChI Key InChIKey=PPZACZHHARMQQU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50393041   

TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 890nMAssay Description:Inhibition of human mPGES-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of human mPGES-1 assessed as production of PGE2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 792nMAssay Description:Inhibition of mPGES-1 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 792nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393041(CHEMBL2152711)
Affinity DataIC50: 885nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed