BDBM50392234 CHEMBL2153190::US8673938, 1

SMILES CCCSc1nc(ccc1C(=O)NC1CCCCC1)N1CCC[C@H](CC(O)=O)C1

InChI Key InChIKey=NCDZABJPWMBMIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50392234   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50392234(CHEMBL2153190 | US8673938, 1)
Affinity DataIC50: 95nMAssay Description:The conversion of cortisone to the active steroid cortisol by 11βHSD1 oxo-reductase activity, can be measured using a competitive homogeneous ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50392234(CHEMBL2153190 | US8673938, 1)
Affinity DataIC50: 96nMAssay Description:Inhibition of N-terminal His6-tagged full length human 11betaHSD1 expressed in baculovirus infected cells using cortisone as substrate after 25 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed