BDBM50392001 CHEMBL2152305

SMILES c1ccc(cc1)CN2CCC(CC2)n3cnc4c3c5cc[nH]c5nc4

InChI Key InChIKey=WKWXJWGOAKGEEM-UHFFFAOYSA-N

Data  4 KI  1 EC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50392001   

TargetTyrosine-protein kinase JAK1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50392001(CHEMBL2152305)
Affinity DataEC50:  86nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL2-induced STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50392001(CHEMBL2152305)
Affinity DataKi:  2.40nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50392001(CHEMBL2152305)
Affinity DataKi:  4.40nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50392001(CHEMBL2152305)
Affinity DataKi:  33nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50392001(CHEMBL2152305)
Affinity DataKi:  85nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed