BDBM50391809 CHEMBL2146887

SMILES c1cc(c(cc1I)F)Nc2c(ccc(c2F)F)C(=O)N3CC(C3)O

InChI Key InChIKey=COACPTNNJAFVAN-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50391809   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 44nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 44nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D3D Structure (crystal)