BDBM50391803 CHEMBL2146888

SMILES c1cc(c(cc1I)F)Nc2c(ccc(c2F)F)C(=O)N3CC(C3)(CN)O

InChI Key InChIKey=GLTAPZSWBNABCW-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50391803   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
TBA

Curated by ChEMBL

LigandBDBM50391803(CHEMBL2146888)Copy SMILESCopy InChI

Affinity DataIC50: 6.60nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
TBA

Curated by ChEMBL

LigandBDBM50391803(CHEMBL2146888)Copy SMILESCopy InChI

Affinity DataIC50: 6.60nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL