BDBM50391730 CHEMBL258741

SMILES COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)n(n2)-c2ccccc2)ccc1O

InChI Key InChIKey=QUOCIDQIFWYHLB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50391730   

TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Rajiv Gandhi Centre For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50391730(CHEMBL258741)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed