BDBM50390261 CHEMBL2070414

SMILES CN1CCN(CCCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C(N)=O)cc3)C2=O)CC1

InChI Key InChIKey=OVHBVEUVOCMYEV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50390261   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Mouse)
Korea University

Curated by ChEMBL

LigandBDBM50390261(CHEMBL2070414)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of IKKbeta in mouse CIA model splenocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Korea University

Curated by ChEMBL

LigandBDBM50390261(CHEMBL2070414)Copy SMILESCopy InChI

Affinity DataIC50: 230nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL