BDBM50389975 CHEMBL2071201

SMILES Cn1cc(Nc2ncc(Br)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cn1

InChI Key InChIKey=GEATXDJAPAHPTP-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50389975   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 1nMAssay Description:Inhibition of Flt3 by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRalpha by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 2nMAssay Description:Inhibition of FGFR2 by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 3nMAssay Description:Inhibition of Aurora A by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDR by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 7nMAssay Description:Inhibition of Lck by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 9nMAssay Description:Inhibition of human KDR autophosphorylation expressed in mouse NIH/3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 13nMAssay Description:Inhibition of KDR by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 34nMAssay Description:Inhibition of GSK3beta by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 42nMAssay Description:Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 44nMAssay Description:Inhibition of Syk by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 82nMAssay Description:Inhibition of PKCepsilon by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389975(CHEMBL2071201)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Wee1 by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed