BDBM50389967 Aminopyrimidine (Scaffold VI)::CHEMBL1614709

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(F)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)cc1C

InChI Key InChIKey=KSOVGRCOLZZTPF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50389967   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50389967(CHEMBL1614709 | Aminopyrimidine (Scaffold VI))
Affinity DataIC50: 140nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389967(CHEMBL1614709 | Aminopyrimidine (Scaffold VI))
Affinity DataIC50: 54nMAssay Description:Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389967(CHEMBL1614709 | Aminopyrimidine (Scaffold VI))
Affinity DataIC50: 19nMAssay Description:Inhibition of human KDR autophosphorylation expressed in mouse NIH/3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389967(CHEMBL1614709 | Aminopyrimidine (Scaffold VI))
Affinity DataIC50: 95nMAssay Description:Inhibition of KDR by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed