BDBM50389823 CHEMBL2070707

SMILES NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1cccc(F)c1F

InChI Key InChIKey=KGCPPJKXODNFLM-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50389823   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389823(CHEMBL2070707)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389823(CHEMBL2070707)
Affinity DataEC50:  100nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin induced check pointMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389823(CHEMBL2070707)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed