BDBM50389728 CHEMBL2069944::US10544104, Compound 132::US9765037, Compound 132

SMILES COc1ccc(cc1C)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=PCSORZRKLIMNAC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50389728   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389728(CHEMBL2069944 | US9765037, Compound 132 | US105441...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389728(CHEMBL2069944 | US9765037, Compound 132 | US105441...)
Affinity DataIC50: 177nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389728(CHEMBL2069944 | US9765037, Compound 132 | US105441...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389728(CHEMBL2069944 | US9765037, Compound 132 | US105441...)
Affinity DataIC50: 177nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389728(CHEMBL2069944 | US9765037, Compound 132 | US105441...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent