BDBM50389703 CHEMBL2070075::US10544104, Compound 148::US9765037, Compound 148

SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C2CCN(C)CC2)c2ncnc(N)c12

InChI Key InChIKey=OKZQYDCLJOBEOA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50389703   

TargetTyrosine-protein kinase ABL1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK-OH as substrate by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human LCK using Ac-EIYGEFKKK-OH as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human p38alpha using myelin basic protein as substrate after 180 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EPHA3 using myelin basic protein as substrate after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CSK using Ac-KKKKEEIYFFF-OH as substrate after 180 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR using poly glu-Tyr as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389703(CHEMBL2070075 | US9765037, Compound 148 | US105441...)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent