BDBM50389070 CHEMBL2064343

SMILES O=c1cc(nc(Cc2nc3ccccc3n2C2CCCCC2)[nH]1)N1CCOCC1

InChI Key InChIKey=FLQGKGPZQLXFCH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50389070   

LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 90nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 142nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 21nMAssay Description:Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi Research & Development

Curated by ChEMBL
LigandPNGBDBM50389070(CHEMBL2064343)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant CPY3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed