BDBM50388988 CHEMBL2063889

SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)Nc1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1

InChI Key InChIKey=YOBQZXHKWPNPCD-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50388988   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50388988(CHEMBL2063889)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Mcl1 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50388988(CHEMBL2063889)
Affinity DataIC50: 85.3nMAssay Description:Binding affinity to N-terminus 6X His-tagged human Bcl2 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50388988(CHEMBL2063889)
Affinity DataIC50: 88.3nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50388988(CHEMBL2063889)
Affinity DataKi:  21.8nMAssay Description:Binding affinity to N-terminus 6X His-tagged human Bcl2 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50388988(CHEMBL2063889)
Affinity DataKi:  24.7nMAssay Description:Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed